What’s best for a work from home headset setup?

Aim for consistency. Always leave the headset charged and always in the same USB port or dock, and then ensure that you position the mic in the same location so that your voice remains smooth. If your room is a little ehoey, adding some soft furnishing can make a big difference. 
Also, check your call app settings: the wrong input device can make even a good headset sound poor. You only need to begin by ensuring you have a comfortable fit and a clear mic, if required you can always upgrade to a more feature packed expensive model if required later.